Sildenafil starts its effect initially after taking Malegra FXT. It pumps up the discharge of nitric oxide across the male reproductive organ. It is this nitric oxide that is hugely liable for the muscle around the penile region to relax, it also aids in the opening up of the blood vessels in that area which aids in the passage of blood to the male reproductive organ. These muscles and vessels also spurt the blood that reaches the male reproductive organ. Sildenafil is a blood thinner and a PDE-5 inhibitor, and this allows for the blood to flow freely and reach its destination in ample amounts. This amount of blood that reaches the male reproductive organ results in it attaining rigidity and an ability to participate and complete the act of copulation. This process is used to counter the erectile dysfunction in men. After this the Fluoxetine will come into the picture to prevent premature discharge. A reduced amount of serotonin in the body is responsible for a premature discharge, and the Fluoxetine is responsible for slowing down the disintegration of serotonin in the body. This causes the male climax to be delayed. Fluoxetine is basically an antidepressant and its usage also results in an alleviation of the depression faced by men.