Avanafil has a unique mechanism against ED as it works on the enzymatic level. It works to inhibit the PDE5 enzyme that degrades a vasodilator called cyclic Guanosine Monophosphate (cGMP). When the body produces cGMP excessively, nitric oxide is also simultaneously secreted. These vasodilators relax the muscles and widen blood vessels allowing higher blood flow to the penile organ. The increased blood augmentation to the phallus helps attain and sustain an erection when you are aroused.