Extra Super Avanafil contains two drugs Avanafil and Dapoxetine treat ED and PE. Avanafil inhibits the PDE5 enzyme and stops the degradation of the cGMP vasodilator. It also helps to secret nitric oxide in a higher amount. Nitric oxide and cGMP relax smooth muscles and widen blood vessels. The increased blood flow leads to a firm phallus when a man is aroused. Dapoxetine works on the brain and increases serotonin levels, which helps you last longer in bed.