Working
Valif 20mg has vardenafil 20mg, a phosphodiesterase type 5 (PDE 5) inhibitor. PDE 5 is a hindrance to achieving erection. It degenerates a cyclic guanosine monophosphate (cGMP), a molecule that helps increase the blood flow into the erectile tissues (corpus cavernosum and corpus spongiosum).
When our body gets sexually stimulated, we feel the sexual urge. Our body releases nitric oxide (NO), which activates cGMP. CGMP is crucial for erection in men. It relaxes the smooth muscles of the blood vessels carrying blood to the penile region.
When relaxed, the blood vessels dilate (widen) and enhance blood flow. This increased blood flow fills the corpus cavernosum and spongiosum, the erectile tissues surrounding the male shaft. As a result, the male reproductive organ gets its hardness and erection.
PDE 5 hydrolyses cGMP and reduces its level in the penile region. Valif 20mg blocks or slows down the effects of PDE 5 on cGMP. As a result, cGMP flourishes in the penile area and helps maintain a continuous blood flow during the act.
Because of this unabated blood flowing into the erectile tissues, the penis can sustain its erection for a longer time and helps the man engage in multiple sessions of copulation.
Dose
The dosages are Valif 10mg for beginners and Valif 20mg for seasoned users. The standard dosage of Valif is 20mg. Take the medication 30-60 minutes before the sexual activity. Take it for the duration and quantity as prescribed. The effect of Valif 20mg on your erection can last 4-5 hours after ingesting.
This 4 - 5 hour is the erection window between which you can attain the erection when you feel the sexual urge or feel stimulated to engage in the sexual activity. After losing the sexual arousal, the erection will also taper off, but you can attain it again as long as the effect of the medication is active in the body.
Take Valif 20mg Dose orally by the mouth. Swallow the whole pill with ample water to absorb the ingredients and avoid dehydration. Do not crush, chew, split, cut, bite, break, or dissolve the pill inside the mouth or outside. You can take it with or without meals.
Many prefer taking it on an empty stomach for a quick kick-in. However, we suggest you take it with a light, healthy, oil and fat-free meal to stay active and energetic during the act. Avoid junk food and heavy, oily, high-fat meals. These meals will delay the absorption and the onset of action.
Avoid smoking, grapefruit juice, alcohol, contraband and recreational drugs and substances, vitamins and herbal supplements, pre-existing or OTC medications, painkillers, antidepressants, or opioids. The maximum daily Valif dose is one pill in 24 hours. Avoid overdosing to get a higher effect or catch up.
You can start with Valif 10mg, and if it does not produce the desired result, upgrade to Valif 20mg after consulting a doctor. A doctor prescribes the medication after examining your body weight, age, diet, lifestyle, medical history, pre-existing and OTC medicines intake, and underlying health conditions. Based on tolerance, health conditions, and response to the medication, the doctor may decrease the Valif dosage to 5mg.
Precautions
Valif 20mg disease contraindication
Heart disease
Compromised heart conditions with heart, cardiac, or cardiovascular diseases, such as coronary artery disease, heart attack, stroke, and heart failure, make Valif 20mg unsafe for use because the medication lowers blood pressure and increases workload on the heart during sexual activity. Avoid the Valif medication if you have a history of unstable angina, arrhythmia, heart blockage, or heart surgery.
Hypertension and hypotension
Patients with uncontrolled high blood pressure (hypertension) and taking blood pressure-lowering medications must avoid Valif 20mg. Valif 20 mg will further push the blood pressure to a lower level, which can be dangerous and life-threatening.
Patients with low blood pressure (hypotension) must use the medication with caution because taking Valif 20mg will cause the blood pressure to fall further, causing fainting, dizziness, and heart problems.
Liver disease
The liver metabolizes the drug. A compromised liver health or a hepatic liver cannot fully process the drug, resulting in drug accumulation in the body that will increase the side effects and drug toxicity. Your doctor may adjust a lower dosage for mild-to-moderate liver conditions. Severe liver health conditions must avoid the Valif medication.
Kidney disease
The kidney excretes the drug from the body. A compromised kidney health or with chronic kidney disease or undergoing dialysis cannot process and excrete the drug from the body or will take longer than usual, leading to drug concentration in the blood, causing toxicity and side effects. Patients with mild-to-moderate kidney conditions may adjust the dosages.
Eye disease
Patients with genetic degenerative eye disease, such as retinitis pigmentosa or non-arteritic anterior ischemic optic neuropathy (NAION), must not use the medication because it may cause a sudden decrease or loss of vision. Patients with glaucoma and high pressure on eyeballs can consult a doctor for dose adjustments.
Prolonged QT interval
Valif 20mg can prolong QT interval, a measure of the heart rhythm, in the electrocardiogram (ECG). Patients with a history of prolonged QT or taking medications that can prolong QT may be at risk of arrhythmia (irregular heartbeat) if taken with Valif 20mg.
Peptic ulcer disease
Patients with peptic ulcers or gastrointestinal bleeding must exercise caution, and Valif 20mg may trigger gastric discomfort or exacerbate the condition. Your doctor may adjust the dosage to deal with it.
Bleeding or blood-related disorders
Patients with bleeding disorders, sickle cell anemia, leukemia, multiple myeloma, hemophilia, and those taking anticoagulant medication may be at risk of bleeding when taken with Valif 20mg because PDE-5 inhibitors can influence platelet functions.
Penile deformity and priapism
Patients having any penile deformity, such as Peyronie's disease, must avoid the Valif medication because it may cause permanent damage to the penile tissues. Patients experiencing priapism after using ED medication must avoid the Valif medication because it may cause permanent and irreversible erectile dysfunction or impotence.
Hearing loss
Valif 20mg may trigger a sudden decrease or loss in hearing or tinnitus (ringing in the ear), as reported by some users. Patients with existing hearing issues can avoid the medication.
Seizure disorders
Patients with a history of seizures must use Valif 20mg with caution. It may reduce the seizure threshold in some users.
Valif 20mg drug interactions
Nitrates
Patients on nitrate medication prescribed for angina (chest pain), such as nitroglycerine, isosorbide dinitrate, and isosorbide mononitrate, must avoid Valif 20mg because it can trigger a severe drop in blood pressure, leading to dizziness, fainting, or heart dysfunction. Avoid recreational drugs, "poppers" such as amyl nitrate and butyl nitrate, as they may cause severe interactions.
Alpha Blockers
Patients using alpha, such as Tamsulosin and doxazosin to treat high blood pressure or benign prostatic hyperplasia, must avoid Valif 20mg because concomitant use of both can cause a severe double effect dip in blood pressure, leading to orthostatic hypotension when standing up. A doctor may adjust the dosage if used for these patients.
CYP3A4 inhibitors
CYP3A4 enzyme helps metabolize Valif 20mg. Inhibiting CYP3A4 will increase drug concentration in the blood, increasing toxicity and side effects. The common CYP3A4 are protease inhibitors, such as ritonavir and indinavir, treating HIV/AIDS, and antifungals, such as ketoconazole and itraconazole, macrolide antibiotics, such as clarithromycin and erythromycin. These medications may require dose adjustments to reduce the Valif 20mg overdose.
CYP3A4 inducers
These drugs reduce the effectiveness of Valif 20mg. It triggers a quicker breakdown of the drug. The common CYP3A4 inducers are rifampin (tuberculosis), carbamazepine, phenytoin (seizures), and St. John's Wort (herbal remedy for depression). Avoid these medications when using Valif 20mg.
Antiarrhythmic medications
Patients with irregular heartbeat use antiarrhythmic medications that can interact with Valif 20mg and increase the QT interval (a measure of heart rhythm). Individuals should not use Valif 20mg when using Antiarrhythmic drugs, such as quinidine, amiodarone, procainamide, and sotalol, as the interaction may cause life-threatening heart arrhythmias.
Blood pressure-lowering medications (antihypertensives)
Patients using antihypertensives, when combined with Valif 20mg, can cause severe hypotensive effects. Avoid antihypertensives, such as beta-blockers, such as metoprolol and propranolol, calcium channel blockers, such as amlodipine, and ACE inhibitors, such as lisinopril and Enalapril.
Anticoagulants and Antiplatelet Drugs
Taking blood thinners, such as warfarin, or antiplatelet drugs, such as aspirin and clopidogrel with Valif 20mg, may increase the risk of bleeding because of the mild effect of PDE5 inhibitors on platelet function.
Warnings
The Valif medication is for men between 18 and 64. Children, adolescents under 18, and older adults above 64 must consult the doctor for pediatric and geriatric applications.
It is not for pregnant and breastfeeding women or those planning pregnancy must avoid it because it may harm the newborn.
Avoid driving, riding, heavy machine handling, or activities that require mental or physical alertness because the Valif medication can make you dizzy, drowsy, and blur the vision.
Avoid smoking, alcohol, grapefruit juice, contraband drugs and substances, recreational drugs, OTC medicines, painkillers, opioids, antidepressants, antihypertensive medication, antifungals, and sedatives because all these may increase the concentration of vardenafil and cause harmful effects.
Store the medication in a cool, dry, moisture-free area, away from children, pets, direct heat, and light, at 20 to 25 degrees centigrade.
Faqs
Can I take blood pressure-lowering medicines with Valif 20mg?
Antihypertensives, when combined with Valif 20mg, can cause severe hypotensive effects. Avoid antihypertensives alpha-blockers (Tamsulosin and doxazosin), beta-blockers (metoprolol and propranolol), calcium channel blockers (amlodipine), and ACE inhibitors (lisinopril and Enalapril).
What is the advantage of Valif 20mg?
It contains vardenafil 20mg. It is a fast-acting (erection within 30 minutes) and long-lasting (up to 4-5 hours) ED treatment.
Can I take Valif 20mg if I have high blood pressure?
Patients with uncontrolled high blood pressure (hypertension) and taking blood pressure-lowering medications avoid Valif 20mg. Valif 20 mg will further push the blood pressure to a lower level, which can be dangerous and life-threatening.
Can I take Valif 20mg if I have low blood pressure?
Patients with low blood pressure (hypotension) must use the medication with caution because taking Valif 20mg will cause the blood pressure to fall further, causing fainting, dizziness, and heart problems.
When can I take Valif 20mg?
Take the valif medication 30-60 minutes before the sexual activity. You should only take the medication when sexually aroused or feeling the sexual urge, or else the medicine may not produce the desired result.
Can I take Valif 20mg if I have liver problems?
The liver metabolizes the drug. A compromised liver health or a hepatic liver cannot fully process the drug, resulting in drug accumulation in the body that will increase the side effects and drug toxicity.
Can I take Valif 20mg if I have kidney problems?
The kidney excretes the drug from the body. A compromised kidney health or with chronic kidney disease or undergoing dialysis cannot process and excrete the drug from the body or will take longer than usual, leading to drug concentration in the blood, causing toxicity and side effects.
What is the correct Valif dose?
The dosages are Valif 10mg for beginners and Valif 20mg for seasoned users. The standard dosage of Valif is 20mg.
How to take Valif 20mg?
Swallow the whole pill with ample water. Do not crush, chew, split, cut, bite, break, or dissolve the pill inside the mouth or outside. You can take it with or without meals.
