Sildigra 250 mg contains sildenafil 250mg, a phosphodiesterase type 5 (PDE 5 inhibitor. It inhibits the action of the enzymes called PDE 5.
Sildigra 250mg does not trigger an erection on ingesting. Sexual arousal is a must for Sildigra 250mg to work. Sexual stimulation causes nitric oxide to be released in the erectile tissues (corpus cavernosum) in the male organ for reproduction.
On the release of nitric oxide, cyclic guanosine monophosphate (cGMP) gets activated in the corpus cavernosum. PDE 5 destroys cGMP in the cells. Sildigra blocks and slows down the effect of PDE 5 on cGMP.
As a result, cGMP flourishes and does its action. It relaxes the smooth muscles of the blood vessels in the penile region, causing them to dilate (open up). These widened blood vessels can enhance the blood flow and fill the erectile tissues in the penile region surrounding the penis.
This increased blood flow resurrects a flaccid penis to hardness and erection. Since cGMP continuously dilates blood vessels, the blood flow is continuously unabated to the penis, leading to a robust and sustained erection for a long duration of sexual activity.
Sildigra ED medication comes in various doses:
Administer the medication as prescribed and for the duration mentioned in the prescription. Take Sildigra 250mg tablet 1-2 hours before the act. Take not more than one pill within 24 hours. Your doctor may decrease the dose based on your tolerance, medical condition, and response to the treatment. Note that you must have a sexual urge before you administer the medication.
Swallow the tablet whole with a glass of water. Do not crush, break, chew, cut, split, or dissolve the tablet in the mouth or outside, as this can affect its effectiveness and produce side effects. You can take it with or without food.
You may take Sildigra on an empty stomach if you want the drug to work faster. We suggest you take a light, healthy, and fat-free meal to stay energetic during the act. Avoid junk food and heavy, oily, and fat-rich meals. They will delay the absorption and the onset.
Avoid smoking, grapefruit juice, alcohol, contraband or recreational drugs and substances, pre-existing or OTC medicines, vitamins, and herbal supplements.
You might have a few common side effects which will wane with time. However, some side effects may persist, or you may experience severe side effects that need medical intervention immediately.
Common Sildigra 250mg Side Effects
Severe Sildigra 250mg Side Effects
Sildigra 250mg Disease Contraindications:
Avoid Sildigra if you have the following health conditions.
Severe heart, cardiac, and cardiovascular issues
Patients with severe heart problems, including unstable angina (unpredictable chest pain), arrhythmia (irregular heartbeat), heart blockage, heart surgery, stroke, heart attack (myocardial infarction), heart failure, or severe aortic stenosis in the past six months or doctors advised not to engage in physical exertion or sexual activity must avoid the medication.
Severe hypotension
Patients with severe hypotension (blood pressure < 90/50mmHg) must not take the Sildigra medication. Taking Sildigra 250mg can plummet the blood pressure level, which can cause fainting, blackout, stroke, heart attack, or severe cardiovascular complications.
Severe liver (hepatic) dysfunction
The liver metabolizes the ED medication. Patients with severe liver ailments must avoid the medication. Liver disorders can accumulate the drug in the body, causing side effects and increased toxicity. Patients with mild-to-moderate liver dysfunction can see a doctor for Sildigra dosage adjustments.
Severe kidney (renal) impairment
Men with severe kidney disorders, such as chronic kidney failure or dialysis, must not take high Sildigra doses like 250mg. The kidney metabolizes and excretes the drug. An impaired kidney function can increase the drug concentration in the body. It risks the man with severe side effects, prolonged erections, and cardiovascular complications. Mild to moderate kidney conditions can take the Sildigra medication after dose adjustments.
Genetic degenerative eye, retinal disorders
Patients with genetic degenerative retinal disorders or eye diseases, such as retinitis pigmentosa and non-arteritic anterior ischemic optic neuropathy (NAION), can face sudden vision loss or decrease or exacerbate the predisposed vision problems. Patients with glaucoma or high pressure on eyeballs must consult a doctor before taking the Sildigra ED medication.
Blood-related or bleeding disorders
Patients with leukemia (blood cancer), multiple myeloma (bone marrow cancer), sickle cell anemia, or any blood-related disorders are at a high risk of priapism (painful and prolonged erection that continues after 4 hours) and must avoid Sildigra 250mg. Men with stomach bleeding, active stomach ulcers, or bleeding disorders like hemophilia or low platelet count must not take the medication because it can affect platelet functions and increase the risk of bleeding. It can worsen the stomach ulcers and cause gastrointestinal bleeding.
Anatomical penile deformity
Men with penile deformities, such as Peyronie’s disease (curvature of the penis) or cavernosal fibrosis, are at an increased risk of priapism or permanent penis damage or impotence when using Sildigra 250mg.
Pulmonary arterial hypertension (PAH)
Patients using Riociguat prescribed for PAH, Guanylate Cyclase, and PDE-5 inhibitors must not use Sildigra 250mg because using them can drop the blood pressure to a low level, which can cause heart problems.
Severe Aortic Stenosis or Hypertrophic Obstructive Cardiomyopathy (HOCM)
Patients with severe aortic stenosis or HCOM must not use Sildigra 250mg because it affects the heart’s ability to pump blood efficiently. It makes it more difficult for the heart. It may also cause a severe drop in blood pressure levels that can cause heart failure or arrhythmia.
Drug Interactions Contraindications:
Avoid Sildigra if you are on these drugs.
Nitrate Medications contraindicated
Alpha-Blockers contraindicated
Blood Pressure-Lowering Medications contraindicated
Protease Inhibitors (HIV/AIDS Treatment) contraindicated
Antifungal Medications contraindicated
Antibiotics contraindicated
Antiarrhythmic Medications contraindicated
Sildigra medication is for men between 18 and 64. Children, adolescents below 18 for pediatric use, and older adults above 64 for geriatric use must consult a doctor.
The medication is not for women. Pregnant and breastfeeding women and those and their male partners planning pregnancy must avoid the medication because it may pass through the blood and may harm the newborn.
Severely dehydrated men caused by vomiting, diarrhea, or excessive sweating must skip Sildigra 250mg until they are hydrated adequately. Dehydration can increase the blood pressure-lowering effects of the drug. Men will be at risk of dizziness, fainting, and other heart-related problems.
Avoid driving, riding, operating, or handling machines, tasks that require physical or mental alertness because the medication can make you dizzy and tired with blurred eyesight.
Avoid smoking, grapefruit juice, alcohol, contraband and recreational drugs, pre-existing or OTC medicines, vitamins, and herbal supplements.
Consult a doctor if you have pre-existing health issues or take medications.
Store the Sildigra medication in a cool, dry, moisture-free area, away from direct heat, light, children, and pets or animals.
Avoid fake Sildigra 250mg or counterfeits as they may contain incorrect chemical composition harmful to your health. Do not accept tampered or broken seal Sildigra strips because they may contain counterfeit Sildigra. Check the expiry date on the packet before opening it.
How long does Sildigra 250 mg last?
The Sildigra can last 4-6 hours depending on the tolerance, age, body weight, diet, lifestyle, pre-existing medicine intake, medical history, underlying health conditions, and response to the treatment.
How fast does the action of Sildigra 250 mg start?
The action is visible within 30-60 minutes after ingestion, depending on sexual stimulation, tolerance, age, body weight, diet, lifestyle, pre-existing medicine intake, medical history, underlying health conditions, and response to the treatment.
What is Sildigra 250mg?
Sildigra 250mg, strictly a prescription-only medication, is a high-dose generic Sildenafil Citrate to treat erectile dysfunction or impotence in men between 18 and 64.
Why should I take Sildigra 250mg?
Doctors resort to the high dose when lower doses like 50 or 100mg do not produce the desired effect. The drug is for cases of severe ED. Sildigra 250 mg is not for first-timers.
What are the common side effects of Sildigra 250mg?
It may cause headache, flushing, vision change or blurry vision, indigestion, nasal stuffiness, palpitation, breathlessness, back or muscle pain.
How to take Sildigra 250mg?
Swallow the Sildigra tablet whole with a glass of water. Do not crush, break, chew, cut, split, or dissolve the tablet in the mouth or outside. You can take it with or without meals. Take it 30-60 minutes before the sexual activity when sexually aroused.
What are the benefits of Sildigra 250mg?
Sildigra 250mg is way higher, more than double the regular doses of 25mg, 50mg, or 100mg commonly prescribed. Men usually take high doses when lower doses, 50 or 100mg, do not produce the desired effect. The Sildigra drug is for cases of severe ED. It improves endurance, vigor, confidence, and performance in the bed.
What are the advantages of Sildigra 250mg?
It is the Sildigra maximum dose for those who have developed tolerance to all other doses. Sildigra 250mg is for those men who did not respond favorably to the standard doses. Since it is a reserved medication with high potency, you will take it only if your doctor prescribes it.
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