Working
How does Sildalis 120mg work?
Inhibition of PDE5 Enzyme
Both sildenafil and tadalafil inhibit the enzyme phosphodiesterase type 5 (PDE5). This enzyme breaks down cyclic guanosine monophosphate (cGMP), a molecule that regulates blood flow in the penis.
As Sildalis 120mg slows the effects of PDE5, cGMP flourishes in the erectile tissues, leading to the relaxation of smooth muscle in the blood vessels of the penis. This relaxation enhances blood flow, which causes an erection.
Increased Blood Flow in Response to Sexual Stimulation
Sildalis only works in the presence of sexual stimulation. During arousal, the release of nitric oxide (NO) triggers the production of cGMP, which Sildalis then amplifies to enhance blood flow and support an erection.
Dose
Standard Dose
Take one tablet of Sildalis 120 mg (100 mg sildenafil + 20 mg tadalafil) about 30–60 minutes before planned sexual activity.
The effects generally last up to 36 hours due to the tadalafil component, giving a prolonged window for sexual activity.
Maximum Frequency
Take Sildalis 120 mg once in 24 hours. Wait at least 24 hours before taking another dose to avoid the risk of side effects and potential overdose.
Administration with Food
You can take Sildalis with or without food, but a high-fat meal may delay its onset by slowing absorption. Taking it on an empty stomach or after a light meal may trigger a rapid kick-in.
Adjust for Side Effects
If the standard dose causes intolerable side effects, consult a doctor. He may recommend a lower dose of a single ED medication, which is less potent than the combined sildenafil and tadalafil effect.
Do Not Alter the Dose
Swallow the Sildalis tablet whole with ample water. Breaking it into pieces may affect the dosage balance and reduce effectiveness.
Avoid Alcohol and Grapefruit Products
Alcohol and grapefruit can interact with Sildalis, increasing the likelihood of side effects such as dizziness and low blood pressure.
Patients with pre-existing diseases
Individuals with certain health conditions (liver or kidney disease, cardiovascular conditions, blood pressure issues) must not take the standard 120 mg. Consulting with a doctor is essential to determine the correct dose and ensure safe use based on individual health needs.
Side Effects
Sildalis (120 mg), which has sildenafil and tadalafil, can have several side effects.
Common Side Effects
These are typically mild and may subside as the body adjusts:
- Headache: The most commonly reported side effect.
- Flushing: A warm, red feeling, especially in the face, neck, and chest.
- Nasal Congestion: Some people experience a stuffy or runny nose.
- Dizziness: Common, especially when standing up too quickly.
- Nausea or Upset Stomach: Some users may experience mild digestive discomfort.
- Back Pain: Occasionally reported because of tadalafil, especially after prolonged use.
- Muscle Pain: Muscle aches can occur and usually resolve within 48 hours.
- Vision Changes: Temporary changes in vision, such as blurred vision or a blue tint.
- Diarrhea: Digestive upset, including diarrhea, may occur.
Severe Side Effects
Priapism
A prolonged, painful erection lasting over 4 hours is a medical emergency, as it can cause permanent damage if untreated.
Severe Vision Changes
Sudden vision loss or blindness, potentially because of non-arteritic anterior ischemic optic neuropathy (NAION). Seek immediate medical help.
Hearing Loss
Sudden reduction or loss of hearing, sometimes accompanied by ringing (tinnitus), needs medical attention.
Chest Pain or Irregular Heartbeat (arrhythmia)
Severe cardiovascular symptoms, such as chest pain, palpitations, or an irregular heartbeat, with existing heart conditions require emergency medical attention.
Severe Allergic Reactions
Swelling of the face, lips, tongue, or throat, difficulty breathing, or severe skin rash could be a sign of anaphylaxis, a life-threatening reaction.
Hypotension (Severely Low Blood Pressure)
Sildalis can cause a significant drop in blood pressure, especially in those taking nitrates or certain blood pressure medications. It can lead to fainting or loss of consciousness.
Severe Skin Reactions
Rare but serious skin conditions like Stevens-Johnson syndrome (SJS) or Toxic Epidermal Necrolysis (TEN) cause blistering and peeling skin. Discontinue use and seek emergency care if a rash occurs.
Severe Shortness of Breath
Breathing difficulties or wheezing may suggest a severe adverse reaction or cardiovascular issue.
Precautions
Nitrate Medications
Avoid Sildalis 120mg with any form of nitrate medication, often prescribed for chest pain (angina). Combining nitrates with Sildalis can cause a severe drop in blood pressure, which can be life-threatening.
Examples of nitrates include nitroglycerin, isosorbide mononitrate, and isosorbide dinitrate.
Severe Cardiovascular Conditions
Individuals with severe heart disease, such as a recent heart attack (within the last 6 months), severe heart failure, or uncontrolled arrhythmias, should avoid Sildalis.
Those with uncontrolled hypertension (high blood pressure) or hypotension (low blood pressure) should also avoid it, as Sildalis can cause blood pressure changes.
History of Stroke
People who have had a recent stroke (within the last 6 months) are at higher risk for cardiovascular events when taking Sildalis.
Severe Liver or Kidney Disease
The liver metabolizes Sildalis 120mg, and the kidneys excrete it. Individuals with severe liver or kidney impairment may have difficulty processing the medication, increasing the risk of side effects.
Retinitis Pigmentosa
This rare genetic eye disorder affects the retina, and individuals with this condition are at a higher risk of severe vision-related side effects.
Severe Vision Loss (NAION)
Individuals who have experienced sudden vision loss or blindness due to non-arteritic anterior ischemic optic neuropathy (NAION) should avoid Sildalis, as it may increase the risk of further vision impairment.
Severe Deformities of the Penis
Conditions such as Peyronie's disease or other anatomical deformities increase the risk of priapism (a prolonged erection).
Blood Disorders
Conditions like sickle cell anemia, multiple myeloma, or leukemia increase the risk of priapism, making Sildalis a less safe option.
Peptic Ulcers and Bleeding Disorders
Sildalis can worsen peptic ulcers and increase the risk of bleeding, so Sildalis 120mg is not for individuals with these conditions.
Allergic Reactions to PDE5 Inhibitors
Individuals allergic to sildenafil, tadalafil, or other ingredients in Sildalis should avoid it. Symptoms of an allergic reaction include rash, itching, swelling, and difficulty breathing.
Concurrent Use of Other PDE5 Inhibitors
Avoid using Sildalis 12mg with other PDE5 inhibitors, as this can increase the risk of side effects and overdose. Avoid combining it with medications like Viagra, Cialis, Levitra, or similar ED medications.
Pregnancy and Lactation
Although Sildalis is for men, women (especially those who are pregnant or breastfeeding) should avoid it because of a lack of safety data.
Pulmonary Hypertension Medications
Avoid combining Sildalis 120mg with PDE5 inhibitors prescribed for pulmonary arterial hypertension, as the combined effects can increase the risk of side effects.
Individuals under 18
Sildalis is not for individuals under the age of 18, as it is for adult men with erectile dysfunction.
Warnings
Risk of Priapism (Prolonged Erection)
Sildalis can cause priapism, a painful, prolonged erection lasting more than 4 hours. Priapism is a medical emergency and can lead to permanent damage to the penis if untreated. Seek immediate medical attention if an erection lasts longer than 4 hours.
Cardiovascular Warnings
Sildalis can affect heart function, particularly in individuals with pre-existing cardiovascular issues. Users with heart conditions such as severe heart disease, recent heart attack, or arrhythmias should use it cautiously. If you experience symptoms of chest pain, dizziness, or shortness of breath, stop taking the medication and seek medical help.
Severe Blood Pressure Drops
Sildalis may cause a significant drop in blood pressure, particularly when combined with nitrate medications (commonly prescribed for chest pain) or alpha-blockers. It can lead to fainting, dizziness, or even a dangerous drop in blood pressure. Avoid alcohol and stay hydrated to help manage blood pressure.
Risk of Vision Loss
Sildalis has a rare but severe side effect: sudden vision loss because of non-arteritic anterior ischemic optic neuropathy (NAION). If you have experienced vision loss or have a condition like retinitis pigmentosa, avoid Sildalis. If you experience sudden vision changes, seek medical attention immediately.
Hearing Loss or Tinnitus
Sudden hearing loss or ringing in the ears (tinnitus) can occur with an intake of Sildalis 120mg. If you notice any sudden changes in hearing, discontinue the medication and consult a healthcare provider.
Allergic Reactions
Allergic reactions to Sildalis can be severe and include symptoms like rash, swelling of the face, lips, tongue, or throat, and difficulty breathing. If you experience any signs of an allergic reaction, stop using Sildalis and seek emergency medical intervention.
Avoid Concurrent Use with Other PDE5 Inhibitors
Do not take Sildalis with other erectile dysfunction medications (like Viagra, Cialis, or Levitra), as this can increase the risk of severe side effects.
Limit Alcohol Intake
Alcohol can increase the likelihood of side effects such as dizziness, low blood pressure, and headaches. It can also reduce the effectiveness of the medication. Limit or avoid alcohol when taking this medication.
Avoid Grapefruit and Grapefruit Juice
Grapefruit products can interfere with Sildalis metabolism, leading to higher Sildalis concentrations in the blood. It can increase the risk of side effects.
Do Not Operate Heavy Machinery or Drive
Sildalis may cause dizziness, drowsiness, or blurred vision. It can reduce your ability to drive or operate machinery. Avoid these activities until you know how the Sildalis affect you.
Use in Specific Populations
Older Patients above 64
Older adults may be more sensitive to Sildalis and are at a higher risk of experiencing side effects.
Patients with liver or Kidney Issues
The liver and kidneys process Sildalis, so individuals with severe liver or kidney impairments should use it cautiously.
Not for Women or Children
Sildalis is only for adult men. Women or children must not administer it.
Consult Before Discontinuing or Adjusting Dose
Do not alter your dose or stop taking Sildalis without consulting a healthcare provider. If you experience side effects, talk to your doctor, who can help adjust the dose or recommend alternatives.
Faqs
Can I take Sildalis 120mg if I have heart disease?
Consult your doctor. Patients with mild-to-moderate heart conditions may take a lower dose of Sildalis under medical supervision, but 120mg may not be suitable, especially if you have active or severe heart ailments or low blood pressure.
What is Sildalis 120mg?
Sildalis 120mg is a medication to treat erectile dysfunction (ED) in men between 18 and 64. The potent active ingredients are Sildenafil Citrate 100mg and Tadalafil 20mg. They deliver a longer duration of action.
How long does the Sildalis 120mg effect last?
It can last up to 36 hours. It enables prolonged effectiveness and more flexibility in timing.
How fast does Sildalis 120mg start its action?
It offers a quick onset of action of 30-60 minutes. The sildenafil component provides a rapid onset of action, usually within 30-60 minutes after ingesting.
Why should I use Sildalis 120mg?
It provides enhanced potency for those who do not get the desired erection at a lower potency ED medication.
What are the benefits of Sildalis 120mg?
By combining these two drugs, Sildalis 120 mg offers a more comprehensive treatment for ED, which can benefit individuals who find single-drug treatments insufficient. The two proven ED treatments in one tablet, Sildalis 120 mg, provide immediate and long-lasting support, making it suitable for individuals looking for flexibility and a potent response.
Can I take Sildalis 120mg if I have liver or kidney dysfunction?
The liver metabolizes Sildalis 120mg, and the kidneys excrete it. Individuals with severe liver or kidney impairment may have difficulty processing the medication, increasing the risk of side effects.
Can I take Sildalis 120mg with blood pressure medications?
Sildalis can cause a significant drop in blood pressure, especially in those taking nitrates or certain blood pressure medications. It can lead to fainting or loss of consciousness.
Can I take Sildalis 120mg if I have heart-related issues?
Sildalis can affect heart function, particularly in individuals with pre-existing cardiovascular issues. Users with heart conditions such as severe heart disease, recent heart attack, or arrhythmias should use it cautiously. If you experience symptoms of chest pain, dizziness, or shortness of breath, stop taking the medication and seek medical help.
Can I take Sildalis 120mg if I have low blood pressure (Hypotension)?
Sildalis may cause a significant drop in blood pressure, particularly when combined with nitrate medications or alpha-blockers blood pressure lowering medicines. Patients who have low blood pressure must avoid Sildalis because it can trigger a dangerous drop in blood pressure, leading to dizziness, fainting, and even death.
