Package 100mg |
Price for new customer |
Price for old customer |
offers | add to cart |
---|---|---|---|---|
8 Pill
(100 Mg)
|
$99 ($12.38 Per Pill) |
$89 ($11.13 Per Pill) |
|
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16 Pill
(100 Mg)
|
$159 ($9.94 Per Pill) |
$143 ($8.94 Per Pill) |
|
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32 Pill
(100 Mg)
|
$189 ($5.91 Per Pill) |
$170 ($5.31 Per Pill) |
|
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48 Pill
(100 Mg)
|
$249 ($5.19 Per Pill) |
$224 ($4.67 Per Pill) |
|
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64 Pill
(100 Mg)
|
$319 ($4.98 Per Pill) |
$287 ($4.48 Per Pill) |
|
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96 Pill
(100 Mg)
|
$399 ($4.16 Per Pill) |
$359 ($3.74 Per Pill) |
|
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128 Pill
(100 Mg)
|
$599 ($4.68 Per Pill) |
$539 ($4.21 Per Pill) |
|
Add to cart |
160 Pill
(100 Mg)
|
$699 ($4.37 Per Pill) |
$629 ($3.93 Per Pill) |
|
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224 Pill
(100 Mg)
|
$799 ($3.57 Per Pill) |
$719 ($3.21 Per Pill) |
|
Add to cart |
Avanafil 100mg is its active ingredient, a phosphodiesterase type 5 (PDE5) inhibitor used primarily to treat erectile dysfunction (ED) in men.
Mechanism of Action
Avana 100mg works by inhibiting the enzyme PDE5, which regulates blood flow in the penis. By blocking the PDE 5 enzyme, Avana 100mg increases blood flow to the penis during sexual stimulation, allowing for a firm erection.
Inhibiting PDE 5 (Phosphodiesterase type 5)
Avanafil is part of a class of drugs called PDE5 inhibitors. The PDE5 enzyme hydrolyzes and breaks down cyclic guanosine monophosphate (cGMP), a molecule that plays a significant role in regulating blood flow in the penis.
During sexual stimulation, our body releases nitric oxide (NO) in the penis, which activates and increases the levels of cGMP. CGMP relaxes the smooth muscles in the blood vessels of the penis, leading to increased blood flow into the spongy tissue of the penis (the corpus cavernosa), which results in an erection.
By inhibiting the PDE5 enzyme, Avana 100mg prevents the breakdown of cGMP, allowing it to accumulate in the penis. This prolonged presence of cGMP maintains the relaxation of the blood vessels, promoting increased blood flow and facilitating a strong, sustained erection.
Response to Sexual Stimulation
Avanafil does not cause an erection on its own; it requires sexual stimulation to be effective. When sexually aroused, Avana 100mg enhances the natural response to erection by improving blood flow to the penis, leading to an erection.
Without sexual stimulation, the body will not release nitric oxide, and cGMP levels will not increase. Therefore, Avana 100mg will not be effective in the absence of sexual arousal.
Rapid Onset of Action
Avana 100mg often affects within 15-30 minutes after ingesting. That is why men prefer Avana 100mg over other ED medications, which may take longer to work.
Duration of Effect
While Avanafil acts quickly, its effects typically last for about 4 to 6 hours, allowing men a sufficient window for sexual activity.
The typical dose of Avanafil (Avana) for erectile dysfunction can vary depending on individual needs and medical advice. The standard doses available are Avana 50 mg, 100 mg, and 200 mg.
For Avana 100 mg, the usual recommendations are:
A doctor might adjust the dose to Avana 200mg or 50 mg based on individual tolerance and response. If 100 mg works well with minimal side effects, doctors will maintain it at that dose.
Take Avana 100 mg as needed, about 15-30 minutes before sexual activity. You can take it with or without meals, but avoid a high-fat meal as it may delay its onset of action.
The usual starting dose is 100 mg, but depending on the response and tolerance, the doctor may adjust the dosage to Avana 50 mg or increase it to Avana 200 mg. Take only one dose per day, and it will only work when there is sexual stimulation.
These side effects are mild and may go away on their own:
These are rare but require immediate medical attention:
Allergic Reactions
In rare cases, some people may experience allergic reactions. Symptoms of an allergic reaction may include:
Administer Avana 100mg with caution in people with certain medical conditions.
Cardiovascular Conditions
Severe Heart Conditions
Individuals with severe heart disease, such as unstable angina, severe congestive heart failure, or heart attack (within the past six months) should avoid Avanafil. Sexual activity may pose an additional strain on the heart, which is risky in these conditions.
Uncontrolled Hypertension or Hypotension
Avanafil can cause drops in blood pressure, which may be dangerous in people with uncontrolled high blood pressure or hypotension.
Recent Stroke
People who suffered a stroke within the past six months should not take Avanafil, as it may increase cardiovascular risk.
Nitrate Medication Use
Nitrates for Chest Pain (angina): Avoid Avana 100mg with nitrate medications, such as nitroglycerin, isosorbide dinitrate, or mononitrate. The combination can lead to a severe and potentially life-threatening drop in blood pressure.
Nitric Oxide Donors
Avoid Avana 100mg with nitric oxide donors like butyl nitrite and amyl nitrite, aka poppers,
Severe Liver Impairment
Avoid Avana 100mg in people with severe liver disease, such as hepatic disorders, fatty liver, and cirrhosis, because the liver metabolizes the medication.
Severe Kidney Impairment
People with severe renal impairment should avoid Avana 100mg, as the kidneys play a significant role in excreting the medication. Accumulation can increase the risk of side effects.
Retinal Disorders
Retinitis Pigmentosa
Individuals with retinitis pigmentosa, a genetic disorder affecting the retina, may be at higher risk of vision problems while taking PDE5 inhibitors like Avanafil.
NAION History
People who have experienced non-arteritic anterior ischemic optic neuropathy (NAION), a condition that can lead to sudden vision loss, are at an increased risk of recurrence if they take Avanafil.
Conditions Predisposing to Priapism
Individuals with conditions that increase the risk of priapism (prolonged and painful erection) must avoid Avana 100mg. It includes people with Sickle Cell Anemia, Multiple Myeloma, Leukemia,
Anatomical Penile Deformation
People with anatomical deformation of the penis, Peyronie's disease, or cavernosal fibrosis should use Avanafil cautiously because of the increased risk of prolonged erection or injury.
Use with Other PDE5 Inhibitors
Avoid Avana 100mg with other PDE5 inhibitors, such as sildenafil, tadalafil, or vardenafil. The combined use can increase the risk of severe side effects, including a dangerous drop in blood pressure.
Bleeding Disorders
Administer Avana 100mg cautiously in people with bleeding disorders or active peptic ulcers, as it may increase the risk of bleeding.
Alpha-Blocker Medications
People taking alpha-blockers for prostate enlargement (BPH) or high blood pressure should use Avanafil with caution. The combination can cause a significant drop in blood pressure, especially when standing up (orthostatic hypotension). Doctors may recommend a stable dose of alpha-blockers before initiating Avana 100mg, and never take it at a different time of day.
Allergic Reaction to Avanafil
Anyone with a known allergy or hypersensitivity to Avana or its components should not take this medication.
Drug interactions
Avana 100mg has specific drug contraindications because of the risk of severe side effects and potential interactions.
Nitrates to treat angina (chest pain)
Strict Avana 100mg contraindications with nitrate medications because it can lead to a dangerous and potentially life-threatening drop in blood pressure. These medications include:
Nitric Oxide Donors
Avoid taking substances like amyl nitrite or butyl nitrite (aka poppers) with Avanafil for the same reason. They can cause severe drops in blood pressure.
Other Phosphodiesterase Type 5 (PDE5) Inhibitors
Avoid taking Avana 100mg alongside other PDE5 inhibitors, such as sildenafil, tadalafil, and vardenafil. Combining Avana 100mg with these drugs can significantly increase the risk of severe side effects, including low blood pressure, visual disturbances, or priapism.
Alpha-Blockers
Alpha-Blockers: Administer Avana 100mg cautiously in people taking alpha-blockers to treat benign prostatic hyperplasia (BPH) or high blood pressure. Examples of alpha-blockers include:
The combination of Avana 100mg and alpha-blockers may lead to severe hypotension (low blood pressure), especially when standing up quickly, causing dizziness, fainting, or falls.
Strong CYP3A4 Inhibitors
CYP3A4 enzyme in the liver metabolizes Avana 100mg. Drugs that strongly inhibit this enzyme can increase drug levels in the blood, increasing the risk of side effects.
Avoid administering Avana 100mg with these drugs or administer it under strict medical supervision, with potential dose adjustments.
Moderate CYP3A4 Inhibitors
Moderate CYP3A4 Inhibitors can also increase drug levels but to a lesser extent than potent inhibitors. Medications include:
CYP3A4 Inducers
CYP3A4 Inducers can reduce the efficacy of Avana 100mg by speeding up its metabolism. Use these drugs cautiously as they can reduce its therapeutic effects:
Other Blood Pressure-Lowering Medications
Avana 100mg can decrease blood pressure. Hence, use it cautiously with other antihypertensive medications, such as ACE inhibitors, beta-blockers, and calcium channel blockers. Combining Avana 100mg with these drugs can lead to an additive hypotensive effect, increasing the risk of fainting or dizziness.
Avana 100mg comes with several warnings and precautions. Users need to ensure it is safe and effective. These warnings pertain to potential health risks, interactions, and conditions that require close monitoring. Below are the warnings:
Alcohol Consumption: Alcohol can enhance the blood pressure-lowering effects of Avanafil, increasing the risk of side effects like dizziness, fainting, headaches, and increased heart rate. Limit alcohol consumption while taking this medication.
Grapefruit Products
Grapefruit and grapefruit juice can interact with Avana 100mg by inhibiting the enzyme CYP3A4, which metabolizes the drug. It can increase the drug concentration in the blood, leading to a higher risk of side effects.
Driving and Operating Machinery
Drowsiness or Dizziness: Avana 100mg may cause dizziness, drowsiness, or blurred vision in some individuals. Avoid driving or operating heavy machinery until you know how the medication affects you.
Pregnancy and Breastfeeding
Avana 100mg is not for women, and avoid it during pregnancy or breastfeeding.
Age Considerations
Avana 100mg is not for individuals younger than 18. In older individuals, exercise caution for potential health concerns, such as cardiovascular risks and drug metabolism changes.
What is Avana 100mg?
Avanafil in Avana 100mg is a phosphodiesterase type 5 (PDE5) inhibitor used to treat erectile dysfunction (ED) in men. It helps increase blood flow to the penis, enabling an erection when sexually stimulated.
How should I take Avana 100mg?
Take Avana 100mg 15 to 30 minutes before sexual activity. You can take it with or without food. The maximum recommended dose is one pill per day.
How does Avana 100mg work?
Avanafil works by inhibiting the PDE5 enzyme, which helps relax the blood vessels in the penis. This relaxation improves blood flow to the area, allowing for an erection in response to sexual stimulation.
How quickly does Avana 100mg work, and how long does it last?
Avanafil can start working within 15 to 30 minutes. Its effects can last 4 to 6 hours, although this varies among individuals.
Who should not take Avana 100mg?
Avana 100mg is not suitable for individuals who take nitrates for chest pain, have severe heart conditions, recent stroke, uncontrolled blood pressure, severe liver or kidney impairment, or have a history of vision problems because of non-arteritic anterior ischemic optic neuropathy (NAION).
Can I take Avana 100mg with alcohol?
Alcohol can increase some of the side effects of Avana 100mg, such as dizziness and lowered blood pressure. It is best to limit alcohol consumption while taking this medication.
Is Avana 100mg safe for people with diabetes?
Yes. Men can administer Avana 100mg with diabetes, but under medical supervision, as people with diabetes may have underlying cardiovascular conditions that require caution.
Can I take Avana 100mg with other ED medications?
No. Avoid Avana 100mg with other PDE5 inhibitors, such as sildenafil, tadalafil, or vardenafil. Combining these medications increases the risk of severe side effects, including dangerously low blood pressure.
Does Avana 100mg affect the fertility?
No, Avana 100mg does not affect sperm count or fertility. It works to improve erections and sexual function. However, it does not directly influence the ability to conceive.
Dalton, Austin, Texas, US
Avana is incredible. I am blown with its rapid kick-in. It is good for on-the-go sessions, in the car when traveling, or for unplanned sessions where you need a fast erection. It worked fine with me at least.
James, Clifton, New Jersey, US
Avana is the quickest and safest. I read a lot about it before switching. I suggest you do the same. Research before changing your brand. It is the new generation drug for ED. It kicks in within 15 minutes, Try an empty stomach.
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