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Sildenafil Citrate Brings Down Heart Stress

Posted by on Friday, January 29, 2010, 3:14
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According to a research, the anti-impotence drug Sildenafil Citrate can reduce the effects of stress on the heart. The drug, used by millions of men, slowed the increase in the strength of heart contractions by half. The Johns Hopkins University study published this research report in its Circulation.Sildenafil Citrate helps men with Erectile Dysfunction by making genital blood vessels expand in order to maintain an erection. However, UK heart experts warned men with heart conditions should talk to their doctor about taking anti-impotence drugs to ensure they use it safely.

The Johns Hopkins team have previously shown Sildenafil Citrate can block the short-term effects of hormonal stress in the heart in mice. Sildenafil Citrate helps maintain erections by blocking the action of an enzyme Phosphodiesterase 5 (PDE5A) which prevents the relaxation of blood vessels in the penis. PDE5A is also involved in the breakdown of a key molecule, cyclic GMP, which helps control stresses and limit heart enlargement. Professor David Kass, the cardiologist who led the study, said, “Sildenafil effectively puts a ‘brake’ on chemical stimulation of the heart.” He further added, “Knowing more about the effects of Sildenafil on heart function will allow for safer evaluation of its use as a treatment for heart problems.”

Dr Charmaine Griffiths, from the British Heart Foundation, said, “Sildenafil Citrate has been a real advance in treating impotence, which affects nearly half of men between 40 and 70 years old.” The findings that Sildenafil Citrate affects blood pressure is not surprising as it was actually being researched for lowering effects on blood pressure, before it was known as a successful treatment for Erectile Dysfunction.