Differences between Sildenafil Citrate and Vardenafil.

Differences between Sildenafil Citrate and VardenafilSildenafil Citrate and Vardenafil are two of the most successful ingredients that help men get rid of Erectile Dysfunction. As these are two different elements, they differ from each other while functioning too.

The most notable differences in both the pills in terms of their function are described below.

The initial dose of Sildenafil Citrate is 50mg which can be titrated up to 100mg and down to 25mg based on efficacy and tolerability. Whereas the initial dose of Vardenafil is 10mg titrated up to 20mg or down to 5mg. Both the pills should be taken once a day only.

Sildenafil Citrate is 10-fold more potent for PDE5 than for PDE6 (present in the retina) and more than 700-fold more potent for PDE5 than for PDE11, whereas Vardenafil is 15-fold more potent for PDE5 than for PDE6 and more than 300-fold more potent for PDE5 than for PDE11.

For people above the age of 65 years, initial dose of Sildenafil Citrate is 25mg whereas it is 5mg in case of Vardenafil.In case of renal insufficiency, Sildenafil Citrate dose can be decreased to 25mg, but the adjustment can not be recommended when one takes Vardenafil.

High-fat meals with medicines like Kamagra,Levitra, Edegra and Sildenafil Citrate decrease maximum plasma concentration by 29% and delay time to maximum plasma concentration by 60 minutes. Whereas high-fat meals with Vardenafil decrease maximum plasma concentration by 18% to 50%, so it can be taken with or without food.

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