PDE 5 Inhibitors-Best Impotence Treatment
PDE 5 inhibitors’ is the specifically designated class of medications that is used to cure male impotence. PDE 5 is the abbreviation of the phosphodiesterase 5 enzyme that is present in the body to regulate the blood supply to the different parts in the body. PDE 5 stabilizes the activity of cGMP and maintains the blood supply to the different parts of the body. PDE 5 is mainly responsible for avoiding the excess of blood supply to the parts in the body. But, when this PDE 5 is produced in excess it affects the blood supply to the different parts of the body and results in improper functioning of the body parts. Simultaneously the blood supply to the penis is reduced and men start facing the problem of the impotence or erectile dysfunction. The more concentration of PDE 5 reduces the amount of cyclic guanoyl monophosphatase in the body and affects the man’s capability to hold the erection.
The inhibition of the PDE 5 certainly helps the men to gain the erection and sustain it too for quite a sufficient time during the sexual intercourse. PDE 5 when produced in excess blocks the blood supply, so by restraining the production of PDE 5 the erectile dysfunction can be cured. PDE-5 inhibitors work by blocking, or inhibiting, the action of PDE-5, an enzyme naturally present in the corpus cavernosum, the spongy erectile tissue of the penis. PDE 5 inhibitors maintain higher levels of cGMP and preserve a satisfactory erection in men. Sildenafil is the first PDE 5 inhibitor discovered by the Pfizer pharmaceuticals. Initially, Sildenafil was tested as a treatment for the angina pectoris, but during the clinical trials it was clear that instead of treating angina pectoris it is giving men a solid and strong erection for about 4 to 6 hours after taking the dose of drug.
Sildenafil worked by enhancing the effects of nitric oxide, a chemical that, upon sexual arousal, is normally produced by cells. When man is sexually excited brain sends the signal in the form of nitric oxide to the penile region that relaxes the penile muscles that in turn open up the arteries and veins that supply blood to the penis. Impotence is observed when these signals from the brain do not reach the penile region or reach to penis but are not intercepted. The intake of Sildenafil affects the neurological system and sends the more signals in the form of nitric oxide to the penis after the sexual stimulation. Sildenafil became a great success as the impotence drugs. Sildenafil is sold in the market as the Viagra, Kamagra, Caverta, etc.
The discovery of the Sildenafil gave rise to a question that whether other PDE 5 inhibitors are useful for the treatment of the impotence. Thus the other PDE 5 inhibitors like Tadalafil and Vardenafil soon came into existence. Tadalafil treated the erectile dysfunction by showing the effect of the drug for about the 36 hours and Vardenafil was same in the effect like the Sildenafil, it showed the effect for about 4 to 6 hours. Thus, the PDE 5 inhibitors developed their own kingdom in the market of the erectile dysfunction drugs. These drugs captured the market of the all the branded drugs that were available to tackle erectile dysfunction. These drugs were sold more than even there branded counterparts. This gave a clear idea that PDE 5 inhibitors are the favorite option of the customers to treat erectile dysfunction.
In a study conducted to know, which is the best method to overcome erectile dysfunction? PDE 5 inhibitors were most acceptable by the patients. Other methods showed around 80% of the success rate, whereas as PDE 5 inhibitors showed 95% of the success rate in treating the erectile dysfunction in men. Thus, it was proved that PDE 5 inhibitors are the best impotence treatment.
